A significant
advancement
in Hep C therapy

EPCLUSA has been shown to effectively treat all 6 main genotypes (GTs) with one pill, once a day for most patients.*

EPCLUSA is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1, 2, 3, 4, 5, or 6 infection with or without cirrhosis (compensated). In those with advanced cirrhosis (decompensated), EPCLUSA is used with ribavirin.

Treatment duration with EPCLUSA is 12 weeks.

Questions about treatment with EPCLUSA?

See TAKING EPCLUSA

If you have Hep C genotype 1, 4, 5, or 6, learn about another treatment option that may be right for you.

*EPCLUSA with ribavirin is recommended for patients with advanced cirrhosis. If you take EPCLUSA with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.

EPCLUSA is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1, 2, 3, 4, 5, or 6 infection with or without cirrhosis (compensated). In those with advanced cirrhosis (decompensated), EPCLUSA is used with ribavirin.

Important Safety Information

What should I tell my healthcare provider before taking EPCLUSA?

  • If you have: liver problems other than hepatitis C infection; severe kidney problems or are on dialysis; any other medical condition; or if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. It is not known if EPCLUSA will harm your unborn baby. If you take EPCLUSA with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.

Continued below

Cure rates
by patient type

Based on clinical studies

GT2 or 3

GT1, 4, 5, or 6

Advanced Cirrhosis*

  • In clinical studies, EPCLUSA has been shown to have high cure rates in patients with Hep C GT2 or GT3, with or without cirrhosis with just 12 weeks of treatment—regardless of Hep C treatment experience.

    Genotype 2 or 3 Patients

    Genotype Weeks of treatment Cure rate
    2 12 99%*
    3 12 95%

    This information does not apply to patients with advanced cirrhosis.

    *In a study of 266 patients with genotype 2 Hep C, with or without prior Hep C treatment, and with or without cirrhosis, who received either EPCLUSA or sofosbuvir + ribavirin for 12 weeks, 99% (133 out of 134) of patients who received EPCLUSA once daily for 12 weeks were cured.

    In a study of 552 patients with genotype 3 Hep C, with or without prior Hep C treatment, and with or without cirrhosis, who received either EPCLUSA for 12 weeks or sofosbuvir + ribavirin for 24 weeks, 95% (264 out of 277) of patients who received EPCLUSA once daily for 12 weeks were cured. Cure rates for EPCLUSA ranged from 89% (with prior Hep C treatment and with cirrhosis) to 98% (without prior Hep C treatment and without cirrhosis).

    Advanced cirrhosis (decompensated) is when the liver is extensively scarred and can no longer do its job effectively.

  • In a clinical study, EPCLUSA has been shown to have high cure rates in patients with Hep C GT1, GT4, GT5 or GT6, with or without cirrhosis, with just 12 weeks of treatment—regardless of Hep C treatment experience.

    Genotype 1, 4, 5, or 6 Patients

    Genotype Weeks of treatment Cure rate
    1 12 98%*
    4 12 100%*
    5 12 97%*
    6 12 100%*

    This information does not apply to patients with advanced cirrhosis.

    *In a study of 740 patients with genotype 1, 2, 4, 5, or 6 Hep C, with or without prior Hep C treatment, and with or without cirrhosis, who received either EPCLUSA or placebo for 12 weeks, 98% (323 out of 328) of patients with genotype 1, 100% (116 out of 116) of patients with genotype 4, 97% (34 out of 35) of patients with genotype 5, and 100% (41 out of 41) of patients with genotype 6, who received EPCLUSA once daily for 12 weeks were cured.

    Advanced cirrhosis (decompensated) is when the liver is extensively scarred and can no longer do its job effectively.

  • Patients Who Have Advanced Cirrhosis Can Be Treated With an EPCLUSA Regimen

    For patients with advanced cirrhosis and Hep C genotype 1–6, EPCLUSA plus ribavirin provides an all-oral treatment option with just 12 weeks of therapy.

    If you have any questions about your treatment regimen, it is important to talk to your Hep C Specialist.

    If you take EPCLUSA with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.

    *Advanced cirrhosis (decompensated) is when the liver is extensively scarred and can no longer do its job effectively.

Learn about common side effects with EPCLUSA

Important Safety Information

What should I tell my healthcare provider before taking EPCLUSA? (continued)

  • Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. EPCLUSA and certain other medicines may affect each other, or may cause side effects. Tell your healthcare provider if you take any medicines containing tenofovir disoproxil fumarate (ATRIPLA®, COMPLERA®, STRIBILD®, TRUVADA®, VIREAD®).

What are the possible side effects of EPCLUSA?

  • EPCLUSA, when taken in combination with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause serious side effects, including slow heart rate. In some cases slow heart rate has led to death or the need for a pacemaker when amiodarone is taken with medicines containing sofosbuvir and another antiviral medicine. Get medical help right away if you take amiodarone with EPCLUSA and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.

Continued below

What is
CIRRHOSIS?

Unfortunately, over time, chronic Hep C can cause a type of liver damage called cirrhosis, which may eventually lead to advanced cirrhosis.

  • Cirrhosis is a type of advanced liver disease in which healthy liver tissue is replaced with scar tissue
  • Advanced cirrhosis (decompensated) is when the liver is extensively scarred and can no longer do its job effectively

To determine if you have cirrhosis, your Hep C Specialist may order a blood test, perform imaging, and/or perform a biopsy to take a closer look at your liver.

Not currently working with a Hep C Specialist?

FIND ONE HERE

Important Safety Information

What are the possible side effects of EPCLUSA? (continued)

  • The most common side effects of EPCLUSA include headache and tiredness. When EPCLUSA is used with ribavirin for those with advanced cirrhosis, they also include anemia, nausea, insomnia, and diarrhea.

EPCLUSA is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1, 2, 3, 4, 5, or 6 infection with or without cirrhosis (compensated). In those with advanced cirrhosis (decompensated), EPCLUSA is used with ribavirin.

Important Safety Information

What should I tell my healthcare provider before taking EPCLUSA?

  • If you have: liver problems other than hepatitis C infection; severe kidney problems or are on dialysis; any other medical condition; or if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. It is not known if EPCLUSA will harm your unborn baby. If you take EPCLUSA with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.
  • Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. EPCLUSA and certain other medicines may affect each other, or may cause side effects. Tell your healthcare provider if you take any medicines containing tenofovir disoproxil fumarate (ATRIPLA®, COMPLERA®, STRIBILD®, TRUVADA®, VIREAD®).

What are the possible side effects of EPCLUSA?

  • EPCLUSA, when taken in combination with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause serious side effects, including slow heart rate. In some cases slow heart rate has led to death or the need for a pacemaker when amiodarone is taken with medicines containing sofosbuvir and another antiviral medicine. Get medical help right away if you take amiodarone with EPCLUSA and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.
  • The most common side effects of EPCLUSA include headache and tiredness. When EPCLUSA is used with ribavirin for those with advanced cirrhosis, they also include anemia, nausea, insomnia, and diarrhea.
SEE MORE +

Important Safety Information

What should I tell my healthcare provider before taking EPCLUSA?

  • If you have: liver problems other than hepatitis C infection; severe kidney problems or are on dialysis; any other medical condition; or if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. It is not known if EPCLUSA will harm your unborn baby. If you take EPCLUSA with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.

Want to find out if EPCLUSA may be right for you? Sign up for Onward and get free step-by-step guidance to start a conversation with your healthcare provider.

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